Rex and Rick Tyler, the first and second Hourmen (miraclo)
Roy Harper, Speedy/Arsenal (heroin)
Steve Rogers Captain America (super soldier serum)
Digger Harkness Capt. Boomerang (miraclo, real or knockoff in ID Crisis)
Jeremy Mcculloch Mirror Master II (cocaine)
Tony Stark Iron Man (alcohol)
Carol Danvers Ms. Marvel/Warbird (alcohol)
Bendis recently introed a Mutant Growth Hormone drug in DD, lots of villains using that.
Bruce Wayne Batman (venom)
Bane (venom)
I know there's more.
