An uplifting movie is Last Holiday

Starring Queen Latifah as a sales employee in a department store, who sees her doctor and is told she has a terminal illness. For 20 years she's had dreams of a trip to Europe and living the vacation of her dreams. And with little time left and nothing to lose, she decides to blow her savings and fulfill her dreams while she can. At the expensive five-star resort, because she spends money so freely she is mistaken for a woman of wealth and influence, and given pretty much free reign by the hotel management and staff, and ends up traveling in high circles with the guests, including a U.S. senator and his lobbyist backers.
Oddly, the freedom of having nothing to lose makes her unafraid to pursue her career interests and love interest, that were both available to her all along. Funny, but also sentimental, and therefore fits in the chick-flick box.

In some ways similar to the movie Joe vs. the Volcano, about a guy similarly working a very unfulfilling job, who has a life-altering event that sends him across the world on a wwild adventure, with Meg Ryan playing multiple roles in the same movie. A bit more quirky and off the wall than Last Holiday, but very pleasant and often hilarious.