I watched a 15 minute sample of the game.
Expect some seriously cheesy combat of nigh linburger proportions when starting act 5. MASSIVE combat, which may leave the one on one combatants like the Bowazon or Paladin in serious shit.
I won't be touching act 5 until my characters are all past level 50 or so.
More storage space and magical socketed weapons sound promising though. I'm stockpiling perfect gems and skulls already.