Rumors from Abrams himself have hinted that they are considering taking a stab at Kirk and Khan's first battle. I bet Sayid from LOST would make a good Khan, though...
Fuck no. That story's been told once already and quite well. That smacks too much of "remake" at this point.
Personally, I've never been able to figure out why the producers of Trek over the past twenty or so years haven't used the Gorn race as a "big bad."
With the exception of a mirror universe cameo on 'Enterprise,' the only time they were ever shown was on a single episode of TOS so you don't have the overuse factor of Romulans, Klingons, Ferengi, etc. What you do have, however, is a race of near invunerable, seven foot tall, predatory, talking lizard people. Those guys could, if written well, eat the Klingons for lunch.
Furthermore, with forty years of advancment in SFX there's no reason you couldn't make them highly realistic looking (and better than the Enterprise version).
Kahn's been done. It's like all the Superman movies that had to keep giving us Luthor over and over. Time to move on.