i was never a huge fan of futurama, but its somewhat silly to think it will be the same show without the original cast. obviously not as jarring that its "only" the voice of the cast, but still. with this in mind, assuming fox isn't bluffing, it might be a wiser idea to create new characters for the show, and shift the original cast to the background (i.e; focus on the flanders / mo's tavern folk, instead of the simpsons family).
then again, voice over work is pretty goddamn easy. if the salaries are close enough, thats a few quick checks for the original crew.