Or at least make this one a send-off for the originals and let the rest stand with a completely new crew of Ghostbuster employees. You could even have more than just the four main spots. But, I don't want a recast of anyone. Brand new characters, with brand new talent. My pick for a new Ghostbuster team would be:
Bill Hader
Seth Green
Jason Segal
Ken Jeong
Kristen Wiig
Donald Glover
With Charlyne Yi taking Annie Potts place as the receptionist...
