1310–1330, many severe winters and cold, wet summers in Europe – the first clear manifestation of the unpredictable weather of the Little Ice Age that lasted for several centuries (from about 1300 to 1900). The persistently cold, wet weather caused great hardship, was primarily responsible for the Great Famine of 1315–1317, and strongly contributed to the weakened immunity and malnutrition leading up to the Black Death (1348–1350).