Most commonly the word Uranus is pronounced ū·rā′·nəs (said like "your anus", emphasis placed on the second syllable) which always seems to get a giggle. For this reason, most in academia have taken to pronouncing it ūr′·ə·nəs (said like "urine iss", emphasis on the first syllable). Either way is acceptable, but when around children, or those that act like children, the latter pronunciation is a safer bet.
