Possibly the first god-like portrayal in comics was the Lee/Kirby introduction of Galactus in FANTASTIC FOUR 48-50.
Of a creature whose power is so far above that of humans, that humans are almost on the level of ants, who can be stepped on by Galactus without even noticing the destruction he causes them.
In this powerful full-page segment the Watcher (a creature approaching Galactus' level of superiority and power) intercedes on the side of humans, and pleads with Galactus to spare Earth.
It's somewhat reminiscent of the scene in Genesis 18:16-33 where God reveals to Abraham He plans to destroy Sodom and Gommorah, and Abraham pleads for God to spare Sodom.
This page was selected for one museum comic book art exhibit I saw.
