Six of one, half a dozen of the other.
Usually, I follow the Character.
A Specific creator usually won't make me pick up a book I hate. Warren Ellis is a favorite of mine, but I won't read his Ultimate Fantastic Four due to the fact that I dispise the Ultimate line. Geoff Johns could write every X-Men book, and I wouldn't touch 'em with a ten foot pole.
Also, there are some writers I will not read, no matter what they do.
For example... I've been a Captain America fan since I've been reading comics. The only time I haven't read a Cap book is when Dan Jurgens was writing, because Jurgens.. .well, he sucks.
I refuse to read anything by Brian Michael Bendis. I dropped Daredevil as soon as he came onboard. If I want pages of Dialogue and no action, I'll read a 1930s Radio script.
I dropped Avengers when Chuck Austen took over, because Austen writes crap.
So, I suppose it all depends.