I wonder if it is possible to make the process in which HIV transcribes itself from RNA to DNA more reliable so that copies are identical to the originals and there is no mutation. It sounds counter-intuitive because you would be assisting the passage of the disease into the human body. However if you can stifle the mutation that occurs on a massive scale as a result of this process then you are effectively pinning the virus down – preventing it from evolving. If you can do that then when it comes to treatment you are aiming at a sitting duck as opposed to a fast moving target that is capable of completely changing its identity every 6 weeks.