I agree that insanity is an overused motivator in literature, and especially comics, and it also leaves open the possibility of Jean being cured.
Another interesting dynamic now also exists between Elongated Man and the Atom.
And I bet we see the Calculator in the pages of Batman (or possibly Birds of Prey, since people have pointed out that the Calculator is the equivalent of Oracle).
Meltzer has painted a lot of new character tension in the DCU with this series. It might be mostly with minor characters (aside from Batman), but its still more characterisation than most of these characters have ever received before.