1. Johnny Depp
2. Edward Norton
After them, no specific order...
3. Bill Murray
4. John Cusack
5. Christopher Walken
6. Bruce Willis
7. Robert DeNiro
8. Samuel L. Jackson
9. Brad Pitt (I think he is an amazing character actor, and was typecast as a leading man just because of his looks.)
10. Ewan McGregor
(Honorable mentions to Gary Oldman, Vince Vaughn, Kevin Spacey, Harvey Keitel, Steve Buscemi, Nicholas Cage, John Corbett, Chow Yun Fat, Bruce Campbell, Morgan Freeman, Al Pacino, George Clooney, Don Cheadle, Michael Chiklis, Kiefer Sutherland, Christian Bale, Tim Roth, James Spader, Zach Braff, John C. McGinley, Laurence Fishburne, Jason Statham...)
Actresses are harder to think of, beyond just "She's hot!". As much as I like certain actresses, I will almost never go to a movie JUST because an actress is in it, while I will with a few of those actors.
1. Kate Winslet
2. Jennifer Connelly
3. Catherine Zeta-Jones
4. Nicole Kidman
5. Scarlett Johansson
6. Alyson Hannigan
7. Cate Blanchett
8. Janeane Garofalo
9. Cameron Diaz
10. Uma Thurman