Actually, I think it would be sweet to make Lois die while having the baby. Who likes the character anymore, anyway? It would give a proper ending to the relationship (that started getting stale when the love triangle ended), and open up new possibilities, like Superman's guilt over being responsible for Lois' death, him being a single parent, and the real possibility of him finding someone else.
Of course, even if someone did something good with that, someone else would still bring her back in a year...
