With the horror craze of the 1970s in full swing, Batman, for the first time since "the Monk" in the 1930s (I think) battled an actual vampire, Detective Comics #455 (1976)
Bruce Wayne’s car breaks down near an old mansion, and soon Batman and Alfred are facing the mansion's vampire resident, who had found a way to transplant his heart outside his body. The Darknight Detective must find the heart's location, in order to stake it to death.
It was, even by the 70s' standards, a pretty outlandish story. But that outlandishness was tempered by the fact that it was one of only times that the great Mike Grell drew Batman.
Grell gave the story an appropriately creepy look, which almost made you believe the silly plot twists. He even modeled the vampire on Christopher Lee. Its too bad that Grell didn't stick around the book for longer, but I suppose the fact that DC picked up "Warlord" about the same time made that pretty much an impossibility.
