Love Maleficent! What an incredible bitch - definitely one of Disney's best villians...
...though Ursala gives her a serious run for her money...
Not even. Ursala doesn't even make top five for pure evil awesomeness. Maleficent is what nightmares are made of!
Shenanigans! Ursala sings, is charming, funny
and Eeeeeevil! G-d I fuckin' love her! How do you NOT sing along to "Poor Unfortunate Souls"?!?!?! It's brilliant! Hell, I'm singin' it right now!

Maleficent is still my fave Disney villian, though. But perhaps the most evil would be the Wicked Queen in Snow White:

"Bring me back her heart" (!!!!!)
Bitch asked for her stepdaughter's
heart!! In a box! WTF!!
Awesome.
Never heard of
Ninja Scroll, though admitedly I'm not an anime fan - unfortunately, the look just turns me off.
Akira's on my netflix list, though as its gotten such good reviews. I'm curious about
Ninja Scroll now and will check it out too.
These five take nothing away from The Incredibles, Sleeping Beauty, Snow White & The Seven Dwarfs, Akira, Heavy Metal, Rock & Rule, Shrek, Cinderella, or Iron Giant. They're all great. These are just my five favorites, though I reserve the right to switch out a few depending on my mood.
Fine I'm adding to my honor role list:
Finding Nemo, Iron Giant, Lion King (Hamlet with a happy ending!),
Snow White, Dumbo, Shrek(the 1st one) and as mentioned already
Cinderella and
Beauty and the Beast...